Epithelial barrier dysfunction in desmoglein-1 deficiency
نویسندگان
چکیده
منابع مشابه
Vitamin D deficiency promotes epithelial barrier dysfunction and intestinal inflammation.
BACKGROUND Vitamin D, an important modulator of the immune system, has been shown to protect mucosal barrier homeostasis. This study investigates the effects of vitamin D deficiency on infection-induced changes in intestinal epithelial barrier function in vitro and on Citrobacter rodentium-induced colitis in mice. METHODS Polarized epithelial Caco2-bbe cells were grown in medium with or witho...
متن کاملProtocadherin-1: Epithelial barrier dysfunction in asthma and eczema.
Affiliations: University of Groningen, University Medical Center Groningen, Beatrix Children’s Hospital, Dept of Pediatric Pulmonology and Pediatric Allergology, Groningen, University of Groningen, University Medical Center Groningen, Laboratory of Allergology and Pulmonary Diseases, Dept of Pathology and Medical Biology, Groningen, and GRIAC Research Institute, University of Groningen, Univers...
متن کاملIntestinal Epithelial Barrier Dysfunction in Food Hypersensitivity
Intestinal epithelial barrier plays a critical role in the maintenance of gut homeostasis by limiting the penetration of luminal bacteria and dietary allergens, yet allowing antigen sampling for the generation of tolerance. Undigested proteins normally do not gain access to the lamina propria due to physical exclusion by tight junctions at the cell-cell contact sites and intracellular degradati...
متن کاملDesmoglein 2-mediated adhesion is required for intestinal epithelial barrier integrity.
The integrity of intercellular junctions that form the "terminal bar" in intestinal epithelium is crucial for sealing the intestinal barrier. Whereas specific roles of tight and adherens junctions are well known, the contribution of desmosomal adhesion for maintaining the intestinal epithelial barrier has not been specifically addressed. For the present study, we generated a desmoglein 2 antibo...
متن کاملRhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1.
Previously, we showed that rhinovirus (RV), which is responsible for the majority of common colds, disrupts airway epithelial barrier function, as evidenced by reduced transepithelial resistance (R(T)), dissociation of zona occludins 1 (ZO-1) from the tight junction complex, and bacterial transmigration across polarized cells. We also showed that RV replication is required for barrier function ...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2018
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2018.04.007